2-氯-8-环戊基-5-甲基-8H-吡啶并[2,3-D]嘧啶-7-酮(帕布昔利布中间体)

Name	Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-chloro-8-cyclopentyl-5-methyl-
Synonyms	Palbociclib intermediates Palbociclib Intermediate2 2-chloro-8-cyclopentyl-5-Me 2-chloro-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7-one 2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one 2-chloro-8-cyclopentyl-5-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one Pyrido[2,3-d]pyriMidin-7(8H)-one, 2-chloro-8-cyclopentyl-5-Methyl- Pyrido[2,3-d]pyrimidin-7(8H)-one, 2-chloro-8-cyclopentyl-5-methyl- 2-Chloro-8-cyclopentyl-5-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (For Palbociclib)
CAS	1013916-37-4
EINECS	800-066-8

Molecular Formula	C13H14ClN3O
Molar Mass	263.72
Density	1.346±0.06 g/cm3(Predicted)
Melting Point	176 - 178°C
Boling Point	428.0±34.0 °C(Predicted)
Water Solubility	Slightly soluble in water.
Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Yellow to Dark Yellow
pKa	0.82±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Use	This product is for scientific research only and shall not be used for other purposes.

Introduction	2-chloro-8-cyclopentyl-5-methyl-8h-pyrido [2,3-D] pyrimidyl-7-one has a melting point of 176 degrees to 178 degrees, a density of 1.3, and an appearance of a yellow or dark yellow solid at normal temperature and pressure. It is generally soluble in chloroform and methanol, and it will be better when heated. It has a certain solubility in water and belongs to heterocyclic aromatic compounds, which can be used as organic synthesis intermediates.
Use	2-chloro-8-cyclopentyl-5-methyl-8h-pyrido [2,3-D] pyrimidyl-7-one is often used as an intermediate in organic synthesis, in which the chlorine atom can be subjected to the corresponding coupling reaction to obtain the product of alkylation and Arylation, the most common application is the introduction of a bromine atom at the position of the double bond near the carbonyl group by bromination.
synthesis method	2-chloro-8-cyclopentyl-5-methyl-8h-pyrido [2, for the synthesis of 3-D] pyrimidyl-7-one, the conventional synthesis method is based on 5-bromo-2-chloro-n-cyclopentanamine pyrimidine -4 Amine, under the action of palladium catalyst, corresponding Heck reaction occurs, and the intermediate product obtained is an acid, and the acid is subjected to intramolecular amine transesterification reaction under the action of anhydride to form lactam compound, the target product can be obtained. Thus, the reaction is actually a two-step reaction.

Last Update：2024-04-09 20:49:11